The Potential Role of Intrathecal Nefopam in the Management of Neuropathic Pain

نویسندگان

  • Mohamed Amin Ghobadifar
  • Navid Kalani
چکیده

Received April 22, 2014. Accepted May 10, 2014. Correspondence to: Mohamed Amin Ghobadifar Department of Student Research Committee, Medicine School, Jahrom University of Medical Sciences, Motahari Avenue, Jahrom, Iran Tel: +98-936-620-8078, Fax: +98-711-636-13-86, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright c The Korean Pain Society, 2014 LETTERS TO EDITORS

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Mechanical Antiallodynic Effect of Intrathecal Nefopam in a Rat Neuropathic Pain Model

Nefopam has a pharmacologic profile distinct from that of opioids or other anti-inflammatory drugs. Several recent studies demonstrate that nefopam has a mechanism of action similar to those of anti-depressants and anticonvulsants for treating neuropathic pain. The present study investigates the mechanical antiallodynic effect of nefopam using immunohistochemical study and western blot analysis...

متن کامل

Intrathecal transplantation of cultured calf chromaffin cells attenuate sensory motor dysfunction in a rat model of neuropathic pain

The potential usefulness of chromaffin cells as a source of neuroactive agents for transplantation in the CNS is based on several promising features, including the diversity of biologically active neurotransmitters, neuropeptides and trophic factors produced by the cells. The purpose of this study was to test the possibility that motor as well as sensory dysfunction is reduced by cultured chrom...

متن کامل

Intrathecal transplantation of cultured calf chromaffin cells attenuate sensory motor dysfunction in a rat model of neuropathic pain

The potential usefulness of chromaffin cells as a source of neuroactive agents for transplantation in the CNS is based on several promising features, including the diversity of biologically active neurotransmitters, neuropeptides and trophic factors produced by the cells. The purpose of this study was to test the possibility that motor as well as sensory dysfunction is reduced by cultured chrom...

متن کامل

Medications in Treatment of Postherpetic Neuralgia

Received December 17, 2013. Accepted December 17, 2013. Correspondence to: Sang Wook Shin Department of Anesthesia and Pain Medicine, Pusan National University School of Medicine, Beomeo-ri, Mulgeum-eup, Yangsan 626-770, Korea Tel: +82-55-360-2752, Fax: +82-55-360-2149, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-...

متن کامل

Spinal Noradrenergic Modulation and the Role of the Alpha-2 Receptor in the Antinociceptive Effect of Intrathecal Nefopam in the Formalin Test

BACKGROUND Nefopam has shown an analgesic effect on acute pain including postoperative pain. The reuptake of monoamines including serotonin and noradrenaline has been proposed as the mechanism of the analgesic action of nefopam, but it remains unclear. Although alpha-adrenergic agents are being widely used in the perioperative period, the role of noradrenergic modulation in the analgesic effect...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 27  شماره 

صفحات  -

تاریخ انتشار 2014